Coronavirus outbreak

A new antibody that can mount a double attack on the Sars-CoV-2 virus by binding to two different sites on the spike protein is starting human trials, leading to hopes of an antibody therapy that can maintain its effectiveness even against new variants of coronavirus.

Professor Johan Neyts, a virologist at the Rega Institute for Medical Research at KU Leuven in Belgium, leads a team searching for drugs that can help us in the fight against Covid-19. His laboratory is part of two projects that are screening millions of compounds to find some that block the coronavirus from replicating and so keep patients from falling sick. He told Horizon about why this search is so important and how it might keep us safe from future pandemics.

Two anti-inflammatory drugs – tocilizumab and sarilumab – as well as steroids, have been identified as potential life-saving coronavirus treatments thanks to a trial set up in the wake of the 2009 swine flu pandemic that mirrors the way that people receive multiple treatments while in intensive care.

A mysterious flu-like illness that caused loss of taste and smell in the late 19th century was probably caused by a coronavirus that still causes the ‘common cold’ in people today, according to Professor Marc Van Ranst at KU Leuven in Belgium, an expert on coronaviruses.

As the first coronavirus vaccines started to be rolled out at the end of a tumultuous 2020, UK officials unexpectedly endorsed stretching the gap between the first and second vaccine dose by up to three months – an approach also considered by other countries.

There was one science story that dominated 2020 and coronavirus is likely to remain a dominant theme in 2021. But from vaccine rollout to lessons for future pandemics and – that other big challenge that we’re facing – climate change, how will the year in science play out? We asked a selection of our interviewees about lessons from 2020 and what needs to happen in their fields in the coming year.

To diagnose and contain the spread of coronavirus, testing is critical. There are two types of Covid-19 tests — those that are designed to detect whether you have the infection now, or those crafted to check whether you have been previously infected by the virus — SARS-CoV-2 — that causes the disease. Like any other product these tests have varying degrees of accuracy and reliability, and can be used to achieve different aims.

From corals bunkering down in deeper waters to wait out climate change stress, to how vaccines can boost our immune system beyond a specific disease – here are the 20 most surprising scientific facts that we discovered this year. 

The virus that causes Covid-19 hijacks human cells by exploiting a ‘doorway’ that is potentially also used by other deadly viruses such as HIV, dengue and Ebola, according to recent research that may help to explain why the coronavirus is so highly infectious to a wide range of organs in the body. 

Dr Yohei Yamauchi, a viral cell biologist at the University of Bristol, UK, who led the research, believes that the finding could not only lead to new drugs against Covid-19, but other anti-viral treatments that could be used to save patients’ lives in future pandemics. 

The world’s first mRNA vaccine has begun its rollout after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two – one made by Pfizer/BioNTech and the other by Moderna – mark the first time this vaccine technology has been approved for use.