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In search of immunity: the science of vaccines
From a universal flu vaccine that could save us from a pandemic, to vaccines that target ticks and mosquitoes, Horizon looks at the science of vaccines during the month of February.

The bacteria that causes TB infects over a quarter of the world’s population, and we speak to the European scientists who are closing in on a vaccine for the disease that could save millions of lives.

We also look at the rise of measles and mumps as a result of fears over the MMR vaccination – and interview researchers who are collecting information to try to prevent unnecessary future vaccine scares.

Mixing different vaccine types is known as a heterologous prime-boost vaccination. It started in the 1990s as a strategy tested by HIV researchers. Image credit - Julia Koblitz / Unsplash

Amid global vaccine rollouts, with nearly 1.2 billion doses currently administered, some countries have recommended a mixed-dose approach where a first prime shot is followed by a booster of a second type. 

Data on the impact of delaying the second dose of mRNA vaccines is still missing, says Mariola Fotin-Mleczek, chief technology officer of CureVac, which is in the late stages of developing a vaccine using this technology. Image credit - U.S. Secretary of Defense/Wikimedia Commons, CC BY 2.0 <https://creativecommons.org/licenses/by/2.0>

As the first coronavirus vaccines started to be rolled out at the end of a tumultuous 2020, UK officials unexpectedly endorsed stretching the gap between the first and second vaccine dose by up to three months – an approach also considered by other countries.

It’s normal for people to experience fever, fatigue or pain at the site of the injection in the first one or two days after the vaccine. Image credit - pexels.com/Gustavo Fring, licenced under pexels licence

The world’s first mRNA vaccine has begun its rollout after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two – one made by Pfizer/BioNTech and the other by Moderna – mark the first time this vaccine technology has been approved for use.

Vaccines can train our innate immune system. Scientists like Christine Stabell Benn are now studying whether a TB vaccine confers protection against Covid-19. Image credit - Lone Morch

Live vaccines can give health effects beyond just protecting us from a specific disease and may even help us combat other infections such as Covid-19, according to Christine Stabell Benn, a professor in global health at the University of Southern Denmark.

People’s willingness to have a vaccine changes depending on how at risk they feel, says anthropologist Heidi Larson. Image credit - RF._.studio/Pexels, licensed under the Pexels licence

Efforts to achieve herd immunity against Covid-19 with a vaccine could be hampered by low levels of confidence in immunisation programs in some European countries, warns Professor Heidi Larson, director of the Vaccine Confidence Project and an anthropologist at the London School of Hygiene and Tropical Medicine, in the UK.

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