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Antibiotic resistance
All over the world, bacteria are becoming resistant to antibiotics, making infections more difficult – and in some cases impossible – to treat. It’s one of today’s biggest public health challenges and this month Horizon examines how scientists are working to overcome this growing issue. We speak to microbiologist Dr Nassos Typas about how we got here, what causes resistance to antibiotics and the different approaches being explored to combat resistance. We look at renewed efforts to find new antibiotics and ask whether it’s possible to reverse antibiotic resistance. And with dairy being a huge food source and also an antibiotic-intensive industry, we speak to scientists who are developing alternative therapies for treating cows for mastitis as a way of curbing antibiotics from coursing through our food chain.
In poorer countries, using raw wastewater to irrigate urban farms could be an underlying cause of antibiotic resistance. Image credit - SuSanA Secretariat, licensed under CC BY 2.0

If you think that the key to beating antibiotic resistance is only for doctors to prescribe less and scientists to find new drug candidates, you are probably wrong. The fundamental solutions may lie far from medicine – in managing our rivers and soils.

Methicillin-resistant Staphylococcus aureus (MRSA) have had their antibiotic resistance reversed in Prof. Almqvist's lab. Image credit - Pixnio/ Janice Haney Carr, Jeff Hageman, M.H.S, USCDCP, licensed under CC0

In the battle against antibiotic resistance, some scientists are trying a new approach: re-sensitising bacteria to drugs they no longer respond to so that existing antibiotics can hit their target once more.

Scientists aim to find new antibiotics that can overcome the resistance of superbugs. Image credit - Flickr/ Sheep purple, licensed under CC BY 2.0

New weapons are needed to fight drug-resistant bacteria, one of the biggest threats to global health. By working on new antibiotics or finding ways to revive existing ones in our medical arsenal, scientists aim to avoid a return to a world where even everyday infections may mean death.

Non-antibiotic drugs may also have a role to play in promoting antibiotic resistance, Dr Typas says. Image credit - Dr Nassos Typas

Finding ways to enlist the bacteria living in our bodies to defend against infections while better understanding their role in promoting antibiotic resistance are key to fighting this growing problem, says Dr Nassos Typas, a microbiologist at the European Molecular Biology Laboratory in Heidelberg, Germany.

Mastitis, a bacterial infection that leads to inflammation of a cow's mammary glands and udders, has long been a scourge of the dairy industry. Image credit - Tomasz Jagielski, licensed under CC BY-SA 3.0

As the global antibiotic resistance crisis grows, chemical-based aerosol sprays and electrical signals to wake up the immune system are being developed to treat cow infections. These non-antibiotic therapies for livestock could also help to limit the spread of antibiotic resistance through the human food chain.

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