[{"command":"add_css","data":[{"rel":"stylesheet","media":"all","href":"\/sites\/default\/files\/css\/css_-kTcRwkqPhQLsqEvdSSyU2XZ3CV5VEleXoE3_xZi2cg.css?delta=0\u0026language=mt\u0026theme=hm_theme\u0026include=eJxLzi9K1U8pKi1IzNErSa0oSSxKTdQtSi3OrEoFAJQ3Cqw"}]},{"command":"openDialog","selector":"#drupal-modal","settings":null,"data":"\u003Cdiv id=\u0022republish_modal_form\u0022\u003E\u003Cform class=\u0022modal-form-example-modal-form ecl-form\u0022 data-drupal-selector=\u0022modal-form-example-modal-form\u0022 action=\u0022\/mt\/article\/modal\/13669\u0022 method=\u0022post\u0022 id=\u0022modal-form-example-modal-form\u0022 accept-charset=\u0022UTF-8\u0022\u003E\u003Cp\u003EHorizon articles can be republished for free under the Creative Commons Attribution 4.0 International (CC BY 4.0) licence.\u003C\/p\u003E\n      \u003Cp\u003EYou must give appropriate credit. We ask you to do this by:\u003Cbr \/\u003E\n      1) Using the original journalist\u0027s byline\u003Cbr \/\u003E\n      2) Linking back to our original story\u003Cbr \/\u003E\n      3) Using the following text in the footer: This article was originally published in \u003Ca href=\u0027#\u0027\u003EHorizon, the EU Research and Innovation magazine\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003ESee our full republication guidelines \u003Ca href=\u0027\/horizon-magazine\/republish-our-stories\u0027\u003Ehere\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003EHTML for this article, including the attribution and page view counter, is below:\u003C\/p\u003E\u003Cdiv class=\u0022js-form-item form-item js-form-type-textarea form-item-body-content js-form-item-body-content ecl-form-group ecl-form-group--text-area form-no-label ecl-u-mv-m\u0022\u003E\n        \n\u003Cdiv\u003E\n  \u003Ctextarea data-drupal-selector=\u0022edit-body-content\u0022 aria-describedby=\u0022edit-body-content--description\u0022 id=\u0022edit-body-content\u0022 name=\u0022body_content\u0022 rows=\u00225\u0022 cols=\u002260\u0022 class=\u0022form-textarea resize-vertical ecl-text-area\u0022\u003E\u003Ch2\u003EWhy dolphins\u2019 arteries don\u2019t age \u2013 and what that means for us\u003C\/h2\u003E\u003Cp\u003EWhile studying the causes of death in large whales during her PhD, Yara Bernaldo de Quir\u00f3s became intrigued by the fact that these marine mammals do not suffer from atherosclerosis or other age-related arterial diseases.\u003C\/p\u003E\u003Cp\u003EA diver herself, she was well aware of how diving affects arterial function. Each dive triggers rapid changes in blood flow and oxygen levels that can strain the arteries over time.\u003C\/p\u003E\u003Cp\u003E\u201cWhat if the evolutionary adaptations to diving are actually protecting whales\u2019 arteries from ageing? That could partly explain why these mammals achieve such long lifespans,\u201d said Bernaldo de Quir\u00f3s, now a biologist at the University of Las Palmas de Gran Canaria in Spain.\u003C\/p\u003E\u003Ch2\u003EPreventing cardiovascular diseases\u003C\/h2\u003E\u003Cp\u003ETo explore this idea further, she reached out to Professor Douglas Seals, a leading authority on cardiovascular and arterial ageing at the University of Colorado Boulder in the United States. He immediately saw promise in her hypothesis.\u003C\/p\u003E\u003Cp\u003ETheir collaboration led to a three-year research initiative called\u0026nbsp;Arterial Aging, funded by a grant from the EU\u2019s Marie Sk\u0142odowska-Curie Actions programme.\u003C\/p\u003E\u003Cp\u003EAt the core of the project is a compelling idea. Marine mammals \u2013 which evolved over millions of years to endure the extreme pressures of deep diving \u2013 may have developed natural mechanisms that protect their arteries from ageing. \u003Cblockquote class=\u0022text-center text-blue font-bold text-2xl w-full lg:w-1\/2 border-2 border-blue p-12 my-8 lg:m-12 lg:-ml-16 float-left\u0022\u003E\n  \u003Cspan class=\u0022text-5xl rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n  \u003Cp class=\u0022font-serif italic\u0022\u003EYou can improve your diet or exercise more, but you can\u2019t stop ageing.\u003C\/p\u003E\n  \u003Cfooter\u003E\n    \u003Ccite class=\u0022not-italic font-normal text-sm text-black\u0022\u003EYara Bernaldo de Quir\u00f3s, Arterial Aging\u003C\/cite\u003E\n  \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n\u003C\/p\u003E\u003Cp\u003EIf confirmed, this discovery could have important implications for preventing cardiovascular disease in humans.\u003C\/p\u003E\u003Cp\u003E\u201cCardiovascular diseases are the leading cause of natural death in Europe, and ageing is the primary non-modifiable risk factor. You can improve your diet or exercise more, but you can\u2019t stop ageing,\u201d said Bernaldo de Quir\u00f3s, who coordinated the EU-funded research effort from June 2021 to May 2024.\u003C\/p\u003E\u003Cp\u003ESince arterial function inevitably declines with age, finding ways to prevent or slow this process could be key to reducing cardiovascular disease risks.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Ch2\u003EA new method\u003C\/h2\u003E\u003Cp\u003ETo test her hypothesis, Bernaldo de Quir\u00f3s and a team at the University of Colorado Boulder developed a new method to study how blood affects arteries. They exposed isolated carotid arteries from young and old mice to blood serum from different sources to observe the effects on artery function.\u003C\/p\u003E\u003Cp\u003EAs a first step, the team tested the effects of mouse blood serum.\u003C\/p\u003E\u003Cp\u003E\u201cAfter being exposed to the blood serum of an old mouse, young arteries exhibited a decline in function, essentially mimicking the behaviour of old arteries,\u201d said Bernaldo de Quir\u00f3s.\u003C\/p\u003E\u003Cp\u003EInterestingly, the reverse was also true. When old arteries were incubated with the blood serum of young mice, their function improved, behaving as if they were younger.\u003C\/p\u003E\u003Cp\u003EThe biologist then conducted the same experiment using human blood serum, which produced similar results.\u003C\/p\u003E\u003Cp\u003EThis was a significant finding. It confirmed that factors present in the circulating milieu \u2013 the molecules found in the bloodstream, whether beneficial (e.g. antioxidants) or harmful (e.g. pro-inflammatory compounds) \u2013 play an important role in arterial health.\u003C\/p\u003E\u003Ch2\u003EGroundbreaking results\u003C\/h2\u003E\u003Cp\u003EIn the final and critical phase of the project, Bernaldo de Quir\u00f3s tested blood serum from bottlenose dolphins \u2013 one of the most accessible and well-studied cetacean species \u2013 across a range of ages.\u003C\/p\u003E\u003Cp\u003E\u201cUnlike what we saw with mouse and human serum, arterial function remained consistently good with bottlenose dolphin serum. Even when arteries from aged mice were incubated with serum from older dolphins, they still maintained healthy function,\u201d she explained.\u003C\/p\u003E\u003Cp\u003EThe results were described as \u201cgroundbreaking\u201d by the American Physiological Society. \u201cThese \u003Ca href=\u0022https:\/\/journals.physiology.org\/doi\/prev\/20240726-aop\/pdf\/10.1152\/ajpheart.00464.2024\u0022\u003Efindings\u003C\/a\u003E suggest that the blood of older dolphins retains youth-like, biologically active factors,\u201d said Seals.\u003C\/p\u003E\u003Ch2\u003ENew avenues of research\u003C\/h2\u003E\u003Cp\u003EThe research carried out by Bernaldo de Quir\u00f3s and Seals has opened up exciting new perspectives for cardiovascular science.\u003C\/p\u003E\u003Cp\u003E\u201cA key goal of future research is to identify the specific factors responsible for this effect,\u201d said Seals.\u003C\/p\u003E\u003Cp\u003EAt this stage, the exact reason why dolphin serum has this protective effect remains unknown. Is it due to the presence of specific beneficial molecules that support arterial function? Or could it be the absence of harmful compounds that typically contribute to ageing?\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cblockquote class=\u0022text-center text-blue font-bold text-2xl w-full lg:w-1\/2 border-2 border-blue p-12 my-8 lg:m-12 lg:-ml-16 float-left\u0022\u003E\n  \u003Cspan class=\u0022text-5xl rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n  \u003Cp class=\u0022font-serif italic\u0022\u003EThese findings suggest that the blood of older dolphins retains youth-like, biologically active factors.\u003C\/p\u003E\n  \u003Cfooter\u003E\n    \u003Ccite class=\u0022not-italic font-normal text-sm text-black\u0022\u003EDouglas Seals, Arterial Aging\u003C\/cite\u003E\n  \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n \u201cWe aim to conduct a large-scale study of the proteins present in the blood, as well as those produced by the arteries after being incubated with different serums, to identify the mechanisms at play,\u201d said Bernaldo de Quir\u00f3s.\u003C\/p\u003E\u003Cp\u003ETo advance this research further, Bernaldo de Quir\u00f3s is teaming up with Professor Laura Mui\u00f1o Mosquera, an associate professor in paediatric cardiology and cardiogenetics at the University of Ghent in Belgium.\u003C\/p\u003E\u003Cp\u003EFor years, Mui\u00f1o Mosquera has been conducting research on Marfan syndrome, a condition characterised by premature or accelerated arterial ageing.\u003C\/p\u003E\u003Cp\u003E\u201cWe hope that the combination of both research approaches will help uncover key mechanisms underlying arterial ageing and potential strategies for its prevention,\u201d said Bernaldo de Quir\u00f3s.\u003C\/p\u003E\u003Ch2\u003EA deeper dive into prevention\u003C\/h2\u003E\u003Cp\u003EWith experiments now underway in the Canary Islands and sample collection progressing in Belgium, the researchers are laying the groundwork for a larger international study.\u003C\/p\u003E\u003Cp\u003EIf early results confirm their initial findings, Bernaldo de Quir\u00f3s and Mui\u00f1o Mosquera plan to apply for further EU research funding to expand the collaboration.\u003C\/p\u003E\u003Cp\u003ETheir goal is to pinpoint what keeps dolphin arteries young and apply that knowledge to fight cardiovascular disease in humans.\u003C\/p\u003E\u003Cp\u003E\u201cThis is just the beginning,\u201d said Bernaldo de Quir\u00f3s. \u201cIf we can understand the natural mechanisms that protect dolphins from arterial ageing, we might one day develop new ways to safeguard human health, too.\u201d\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EResearch in this article was funded by the EU\u2019s Marie Sk\u0142odowska-Curie Actions (MSCA) programme. The views of the interviewees don\u2019t necessarily reflect those of the European Commission. 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