[{"command":"openDialog","selector":"#drupal-modal","settings":null,"data":"\u003Cdiv id=\u0022republish_modal_form\u0022\u003E\u003Cform class=\u0022modal-form-example-modal-form ecl-form\u0022 data-drupal-selector=\u0022modal-form-example-modal-form\u0022 action=\u0022\/en\/article\/modal\/12401\u0022 method=\u0022post\u0022 id=\u0022modal-form-example-modal-form\u0022 accept-charset=\u0022UTF-8\u0022\u003E\u003Cp\u003EHorizon articles can be republished for free under the Creative Commons Attribution 4.0 International (CC BY 4.0) licence.\u003C\/p\u003E\n \u003Cp\u003EYou must give appropriate credit. We ask you to do this by:\u003Cbr \/\u003E\n 1) Using the original journalist\u0027s byline\u003Cbr \/\u003E\n 2) Linking back to our original story\u003Cbr \/\u003E\n 3) Using the following text in the footer: This article was originally published in \u003Ca href=\u0027#\u0027\u003EHorizon, the EU Research and Innovation magazine\u003C\/a\u003E\u003C\/p\u003E\n \u003Cp\u003ESee our full republication guidelines \u003Ca href=\u0027\/horizon-magazine\/republish-our-stories\u0027\u003Ehere\u003C\/a\u003E\u003C\/p\u003E\n \u003Cp\u003EHTML for this article, including the attribution and page view counter, is below:\u003C\/p\u003E\u003Cdiv class=\u0022js-form-item form-item js-form-type-textarea form-item-body-content js-form-item-body-content ecl-form-group ecl-form-group--text-area form-no-label ecl-u-mv-m\u0022\u003E\n \n\u003Cdiv\u003E\n \u003Ctextarea data-drupal-selector=\u0022edit-body-content\u0022 aria-describedby=\u0022edit-body-content--description\u0022 id=\u0022edit-body-content\u0022 name=\u0022body_content\u0022 rows=\u00225\u0022 cols=\u002260\u0022 class=\u0022form-textarea ecl-text-area\u0022\u003E\u003Ch2\u003EGenetic testing breakthrough helps women with high risk of breast cancer avoid surgery\u003C\/h2\u003E\u003Cp\u003EThey call it the Angelina Jolie effect: the popular belief that only a preventative double mastectomy can safeguard a woman from developing a tumour if she carries gene mutations linked to breast cancer.\u003C\/p\u003E\u003Cp\u003ECelebrity actress Jolie made headlines in 2013 when she underwent radical breast surgery after genetic testing revealed she carried a gene \u2013 BRCA1 \u2013 that significantly increased her odds of developing breast and\/or ovarian cancer.\u003C\/p\u003E\u003Cp\u003EFast forward a decade and eight more genes known to raise a woman\u2019s susceptibility to breast cancer have been discovered. Among these are BRCA2, which also greatly increases the chances of developing breast cancer, and four genes discovered by\u0026nbsp;\u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/634935\u0022\u003EBRIDGES\u003C\/a\u003E, an international research project funded by the EU.\u003C\/p\u003E\u003Cp\u003EThanks in large part to ground-breaking work by EU-funded researchers,\u0026nbsp;prophylactic surgery is no longer seen as inevitable for a woman to stay healthy if she carries a gene that increases her risk of breast cancer.\u003C\/p\u003E\u003Cp\u003EIn parallel to these discoveries, medical understanding of risk \u2013 the likelihood of a woman developing breast cancer if she carries specific mutations \u2013 has also evolved significantly.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAvoiding surgery where possible\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EGreater clarity around the level of risk and the treatment options available is welcomed by women\u2019s cancer support groups.\u003C\/p\u003E\u003Cp\u003E\u2018The ideal outcome of genetic screening is for women to get an accurate picture of their risk and be offered a personalised approach to tumour prevention,\u2019 said\u0026nbsp;Marzia Zambon, executive director of\u0026nbsp;\u003Ca href=\u0022https:\/\/www.europadonna.org\/\u0022\u003EEuropa Donna\u003C\/a\u003E, Europe\u2019s largest breast cancer advocacy group.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u2018We\u2019re pushing for genetic testing to always be done with the professional guidance of a genetic counsellor. If testing isn\u2019t done right, it can cause a lot of stress and an unnecessary escalation of treatment.\u2019\u003C\/p\u003E\u003Cp\u003E\u003Cblockquote class=\u0022tw-text-center tw-text-blue tw-font-bold tw-text-2xl lg:tw-w-1\/2 tw-border-2 tw-border-blue tw-p-12 tw-my-8 lg:tw-m-12 lg:tw--ml-16 tw-float-left\u0022\u003E\n \u003Cspan class=\u0022tw-text-5xl tw-rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n \u003Cp class=\u0022tw-font-serif tw-italic\u0022\u003EBetter precision in predicting breast cancer makes it easier for women to make informed choices.\u003C\/p\u003E\n \u003Cfooter\u003E\n \u003Ccite class=\u0022tw-not-italic tw-font-normal tw-text-sm tw-text-black\u0022\u003EDr Marjanka Schmidt, B-CAST\u003C\/cite\u003E\n \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n\u003C\/p\u003E\u003Cp\u003EResearchers involved in BRIDGES and\u0026nbsp;\u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/633784\u0022\u003EB-CAST\u003C\/a\u003E \u2013 another EU-funded research initiative \u2013 have made huge advances in showing how both genes, lifestyle and environmental factors influence the risk of breast cancer. These non-genetic factors include a woman\u2019s exposure to pollution, excess body weight, breast tissue density, low physical activity, alcohol consumption, exposure to birth control and other hormones, and the number of children borne.\u003C\/p\u003E\u003Cp\u003E\u2018Until recently, genetic testing could identify women carrying genes linked to breast cancer, but estimates of the risk these women were facing were quite imprecise,\u2019 said\u0026nbsp;Professor Peter Devilee, BRIDGES research coordinator and cancer geneticist at Leiden University in the Netherlands. This matters because imprecise risk evaluation can result in inaccurate treatment advice.\u003C\/p\u003E\u003Cp\u003E\u2018Women with a family history of breast cancer are being referred to labs for genetic testing, and mutations are being identified, but if you can\u2019t translate a result into a fairly precise breast cancer risk, it can lead to improper risk management advice. We wanted to help clinics interpret results properly.\u2019\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPredicting with precision\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EIn their quest to estimate the risk posed by any given gene mutation more precisely, the BRIDGES researchers sequenced all suspected breast cancer genes in the genomes of\u0026nbsp;\u003Ca href=\u0022https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1913948\u0022\u003E113\u0026nbsp;000 women\u003C\/a\u003E. Of these women, half were known to have had a breast cancer diagnosis, while the other half had not.\u003C\/p\u003E\u003Cp\u003EThe genetic profiles of these patients were then crosslinked with data from 20\u0026nbsp;000 breast tumours analysed by the B-CAST team. In addition, the B-CAST researchers contributed information about the genetic profiles of patients\u2019 close family members and those all-important lifestyle and environmental risks.\u003C\/p\u003E\u003Cp\u003EThe BRIDGES team contributed an added tranche of data\u0026nbsp;on genes that hadn\u2019t yet been implicated in breast cancer, but which might impact the risk to develop breast cancer when appearing in a mutated form.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFinally, all this information was combined with the findings of earlier EU-funded research efforts which set out to find common DNA variations in the\u0026nbsp;same cohort of women, including\u0026nbsp;\u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/223175\u0022\u003ECOGS\u003C\/a\u003E, the world\u2019s largest project on genome-wide association studies to predict cancer risk.\u003C\/p\u003E\u003Cp\u003EThe result of all this data crunching? The BRIDGES and B-CAST teams were able to make vast improvements to a pre-existing tool that estimates the risk posed by any given gene mutation or combination of mutations.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ENamed\u0026nbsp;\u003Ca href=\u0022https:\/\/www.canrisk.org\/\u0022\u003ECanRisk\u003C\/a\u003E, this online tool, available in seven EU languages, is designed to give an expert \u2013 usually a clinical geneticist \u2013 an accurate estimate of a woman\u2019s risk of developing a specific type of tumour. The higher the score, the greater the risk.\u003C\/p\u003E\u003Cp\u003EThe hope is that more women with moderate-to-high risk of breast cancer will be identified early.\u0026nbsp;CanRisk factors in the subtype of cancer linked to each cancer gene or gene combination. This is important as some tumour subtypes are far more dangerous than others and treatment options, as well as likely health outcomes, differ from subtype to subtype.\u003C\/p\u003E\u003Cp\u003EA handful of European clinics are currently piloting the user-friendly, CE-marked CanRisk tool. The researchers are hopeful that more will come on board in the years ahead.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMore choices, better screening\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBeing informed of an elevated risk for developing breast cancer is important, but what actions should a woman take upon receiving this information?\u003C\/p\u003E\u003Cp\u003E\u2018Better precision in predicting breast cancer makes it easier for women to make informed choices about their bodies and their health,\u2019 said Dr\u0026nbsp;Marjanka Schmidt, B-CAST coordinator and an\u0026nbsp;epidemiologist with an expertise in breast cancer genetics based in the Netherlands.\u003C\/p\u003E\u003Cp\u003E\u2018Ultimately, it cuts overtreatment and reduces the incidence of unnecessary, life-changing surgery.\u2019\u003C\/p\u003E\u003Cp\u003E\u003Cblockquote class=\u0022tw-text-center tw-text-blue tw-font-bold tw-text-2xl lg:tw-w-1\/2 tw-border-2 tw-border-blue tw-p-12 tw-my-8 lg:tw-m-12 lg:tw--ml-16 tw-float-left\u0022\u003E\n \u003Cspan class=\u0022tw-text-5xl tw-rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n \u003Cp class=\u0022tw-font-serif tw-italic\u0022\u003EWe wanted to help clinics interpret results properly.\u003C\/p\u003E\n \u003Cfooter\u003E\n \u003Ccite class=\u0022tw-not-italic tw-font-normal tw-text-sm tw-text-black\u0022\u003EProfessor Peter Devilee, BRIDGES\u003C\/cite\u003E\n \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n\u003C\/p\u003E\u003Cp\u003ETypically, women who are identified as at-risk using the CanRisk tool are offered mammograms from an earlier age than other women and\/or more frequent mammograms. MRI scans might also be added to their screening protocol.\u003C\/p\u003E\u003Cp\u003E\u2018CanRisk has brought clear benefits to many, leading to reductions in the occurrence, severity and mortality of breast cancer. And as we continue to refine the tool, it\u2019s likely to save more and more lives,\u2019 said Schmidt, who leads a research group at the Netherlands Cancer Institute and is a professor of genetic epidemiology of (breast) cancer at Leiden University Medical Center.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ENext steps\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe research carried out by the BRIDGES and B-CAST teams between 2015 and 2021 has continued well beyond the initial funding provided by the EU.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe B-CAST team are now developing a tool that will help cancer doctors more accurately predict the health benefits of a specific course of treatment for a given woman with a given subtype of breast cancer.\u003C\/p\u003E\u003Cp\u003E\u2018Some treatments have quite serious side-effects, so it\u2019s important for women and clinicians to know how much impact a particular treatment is likely to have on the tumour, and for decisions to be based on the survival benefits of this treatment,\u2019 said Schmidt.\u003C\/p\u003E\u003Cp\u003EMeanwhile, the BRIDGES researchers continue in their quest to identify further genes associated with breast cancer.\u003C\/p\u003E\u003Cp\u003E\u2018We know about 55-60% of the genetic risk factors, but that leaves 40-45% that still need to be discovered,\u2019 said Devilee.\u003C\/p\u003E\u003Cp\u003EThe combined impact of their research is already being felt. It will continue to help guide both doctors and patients on the best way to decrease both the incidence of breast cancer and the human toll of this disease.\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EResearch in this article was funded by the EU\u2019s Horizon Programme. The views of the interviewees don\u2019t necessarily reflect those of the European Commission. If you liked this article, please consider sharing it on social media.\u003C\/em\u003E\u003C\/p\u003E\u003C\/textarea\u003E\n\u003C\/div\u003E\n\n \u003Cdiv id=\u0022edit-body-content--description\u0022 class=\u0022ecl-help-block description\u0022\u003E\n Please copy the above code and embed it onto your website to republish.\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003Cinput autocomplete=\u0022off\u0022 data-drupal-selector=\u0022form-lsfqafxldrnyholnor7wq02asbbxoa2zz-agzrczwhw\u0022 type=\u0022hidden\u0022 name=\u0022form_build_id\u0022 value=\u0022form-LSfqafxldrNYhOlnoR7wq02ASBBxOA2zZ-AGZrCzWhw\u0022 \/\u003E\n\u003Cinput data-drupal-selector=\u0022edit-modal-form-example-modal-form\u0022 type=\u0022hidden\u0022 name=\u0022form_id\u0022 value=\u0022modal_form_example_modal_form\u0022 \/\u003E\n\u003C\/form\u003E\n\u003C\/div\u003E","dialogOptions":{"width":"800","modal":true,"title":"Republish this content"}}]