[{"command":"add_css","data":[{"rel":"stylesheet","media":"all","href":"\/sites\/default\/files\/css\/css_-kTcRwkqPhQLsqEvdSSyU2XZ3CV5VEleXoE3_xZi2cg.css?delta=0\u0026language=cs\u0026theme=hm_theme\u0026include=eJxLzi9K1U8pKi1IzNErSa0oSSxKTdQtSi3OrEoFAJQ3Cqw"}]},{"command":"openDialog","selector":"#drupal-modal","settings":null,"data":"\u003Cdiv id=\u0022republish_modal_form\u0022\u003E\u003Cform class=\u0022modal-form-example-modal-form ecl-form\u0022 data-drupal-selector=\u0022modal-form-example-modal-form\u0022 action=\u0022\/cs\/article\/modal\/9149\u0022 method=\u0022post\u0022 id=\u0022modal-form-example-modal-form\u0022 accept-charset=\u0022UTF-8\u0022\u003E\u003Cp\u003EHorizon articles can be republished for free under the Creative Commons Attribution 4.0 International (CC BY 4.0) licence.\u003C\/p\u003E\n      \u003Cp\u003EYou must give appropriate credit. We ask you to do this by:\u003Cbr \/\u003E\n      1) Using the original journalist\u0027s byline\u003Cbr \/\u003E\n      2) Linking back to our original story\u003Cbr \/\u003E\n      3) Using the following text in the footer: This article was originally published in \u003Ca href=\u0027#\u0027\u003EHorizon, the EU Research and Innovation magazine\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003ESee our full republication guidelines \u003Ca href=\u0027\/horizon-magazine\/republish-our-stories\u0027\u003Ehere\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003EHTML for this article, including the attribution and page view counter, is below:\u003C\/p\u003E\u003Cdiv class=\u0022js-form-item form-item js-form-type-textarea form-item-body-content js-form-item-body-content ecl-form-group ecl-form-group--text-area form-no-label ecl-u-mv-m\u0022\u003E\n        \n\u003Cdiv\u003E\n  \u003Ctextarea data-drupal-selector=\u0022edit-body-content\u0022 aria-describedby=\u0022edit-body-content--description\u0022 id=\u0022edit-body-content\u0022 name=\u0022body_content\u0022 rows=\u00225\u0022 cols=\u002260\u0022 class=\u0022form-textarea resize-vertical ecl-text-area\u0022\u003E\u003Ch2\u003EWe eat and inhale thousands of bits of plastic every year. Now what?\u003C\/h2\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003EPlastic bottles, bags and containers, toothbrushes, tires and electronics litter coastlines, float in the sea and clog landfill sites. What about the plastic waste we can\u2019t see?\u003C\/p\u003E\n\n\u003Cp\u003EWhen the plastic litter in our waterways and on the ground gets weathered and degrades, it eventually breaks down into millions of smaller and smaller pieces. Plastic specks smaller than five millimetres are called microplastics. Nanoplastics are even smaller (some are 500 times smaller than a human hair). While exposure to air pollutants have been associated with health impacts, including higher risk of respiratory infections, heart disease and lung cancer, science still lacks evidence about how microplastics and nanoplastics are affecting the human body.\u003C\/p\u003E\n\n\u003Cp\u003EIn 2019, the World Health Organization (WHO) published its first report on the effects of microplastics on human health. It concluded that there is not enough data yet on humans to know if microplastic particles are hurting us. The WHO called for more research into microplastics.\u003C\/p\u003E\n\n\u003Cp\u003EThat\u2019s exactly what is being done in laboratories across Europe. Spearheading efforts in research on micro- and nanoplastics (MNPs), the European Research Cluster to Understand the Health Impacts of Micro- and Nanoplastics (\u003Ca href=\u0022https:\/\/cusp-research.eu\/about\/\u0022\u003ECUSP cluster\u003C\/a\u003E) was formed in April 2021 by five multidisciplinary research consortia: \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/964827\u0022\u003EAURORA\u003C\/a\u003E, \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965173\u0022\u003EImptox\u003C\/a\u003E, \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965196\u0022\u003EPLASTICHEAL\u003C\/a\u003E, \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965367\u0022\u003EPlasticsFatE \u003C\/a\u003Eand \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/964766\u0022\u003EPOLYRISK\u003C\/a\u003E.\u003C\/p\u003E\n\n\u003Cp\u003EThis consortium of scientists, industry and policymakers are collaborating in the largest effort so far in Europe to uncover the complex relationship between MNPs and human health, from early life to adulthood.\u003C\/p\u003E\n\n\u003Cp\u003E\u2018All five projects are working towards the same direction in terms of providing solid scientific evidence and data to inform the risk managers in Europe and elsewhere about potential risks,\u2019 said Professor Tanja Cirkovic Veli\u010dkovi\u0107 who is Coordinator of Imptox and oversees the CUSP cluster in the first year of its implementation. \u2018At the moment we have a very limited data on exposures and risks, which makes risk management a challenging task. The European Commission has initiated steps to address this \u003Ca href=\u0022https:\/\/ec.europa.eu\/environment\/topics\/plastics\/microplastics_en\u0022\u003Eimportant science policy issue\u003C\/a\u003E.\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003EThe aim of CUSP is to provide the scientific data risk managers need to decide what kinds of actions could be needed to protect humans and the environment from potential adverse effects. Currently, there is no single European law that covers microplastics in a comprehensive manner. The timing is perfect. The EU is planning an upcoming \u003Ca href=\u0022https:\/\/ec.europa.eu\/environment\/topics\/plastics\/microplastics_en\u0022\u003Einitiative \u003C\/a\u003Eon microplastics, with a public consultation slated to launch this year.\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003EBased on the work undertaken, risk assessments will be carried out to identify the potential hazards and provide evidence to strategies and policies for better prevention and response. According to Roel Vermeulen, Professor of Environmental Epidemiology and Exposome Science and Director of the Institute for Risk Assessment Sciences at Utrecht University, the Netherlands, it\u2019s time to map existing regulations and conduct the right experiments and research to identify the gaps and find ways to fill them.\u003C\/p\u003E\n\n\u003Cp\u003E\u2018Understanding the potential gaps in current particle and chemical risk assessment with respect to MNPs and early life health is what we\u2019ve been working on during our first year,\u2019 said Prof. Vermeulen who also heads the AURORA consortium. \u2018Our goal at the end of the project is to provide a roadmap for the European Commission and to show whether or not we are covered by current regulations. We know that there are gaps, we just don\u2019t know how large these gaps are and how deficient or sufficient current legislation is. I think these are the questions the entire CUSP consortium will need to answer.\u2019\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003E\u003Cstrong\u003EThe potential effects of microplastics on foetuses\u003C\/strong\u003E\u003C\/p\u003E\n\n\u003Cp\u003EFor Prof. Vermeulen and his AURORA team, the biggest question concerns the presence of potentially harmful plastic particles scientists have found in human placentas. They are investigating MNP exposures and toxicological and health effects during pregnancy and in early life.\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003E\u2018We know that some of the chemicals related to micro- and nanoplastics have consequences in early life health if we think about developmental effects,\u2019 he said. \u2018If we look at air pollution research, we also see there is an effect of particles on birth weight and cognitive development. We also know that small particles in the air can cross the placenta barrier and directly expose the foetus. This is why it\u2019s very important now to evaluate the impact of what specifically micro- and nanoplastics do during pregnancy and early life.\u2019\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003E\u2018Among the emerging contaminants, microplastics are the ones we are really interested in because even though they are all around us, and inside our bodies, we still don\u2019t know what they do to us,\u2019 explained Prof. Cirkovic Veli\u010dkovi\u0107, who is investigating the possibility that high concentrations of MNPs in the environment could increase the number of allergy sufferers or worsen their allergies.\u003C\/p\u003E\n\n\u003Cp\u003E\u003Cstrong\u003EThe relationship between MNPs, allergic diseases and asthma\u003C\/strong\u003E\u003C\/p\u003E\n\n\u003Cp\u003EBuilding on her primary research interests related to allergy \u2013 one of the most common chronic diseases in Europe \u2013 Prof. Cirkovic Veli\u010dkovi\u0107 has studied the impact of environmental changes on allergenic proteins. Now she\u2019s looking into MNPs. \u2018Very little is known about how MNPs influence allergic disease,\u2019 she said.\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003ETo fill this knowledge gap, the Imptox scientists are investigating the complex role of MNPs combined with environmental contaminants such as heavy metals, allergens and microorganisms in food safety and human health, focusing on allergy and asthma.\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003E\u2018In the Imptox project, we will study for the first time the effects of environmental or dietary exposure to MNPs on allergy and asthma,\u2019 explained Prof. Cirkovic Veli\u010dkovi\u0107. \u2018We expect to find evidence of the impact of micro- and nanoplastics on allergic diseases. Currently this is information that doesn\u2019t exist.\u2019\u003C\/p\u003E\n\n\u003Cp\u003EThe Imptox multidisciplinary team brings together universities, research institutions, and small- and medium-sized enterprises from eight countries (Austria, Belgium, Croatia, France, Italy, Serbia, Sweden and Switzerland). The project also extends beyond Europe by cooperating with scientists from the South Korean campus of Ghent University supplying samples from the Yellow Sea coastal areas (known for pollution problems). The overall aim is to develop innovative tools to identify, extract, characterise and quantify MNPs and to investigate toxicity and responses to MNPs, contaminants and allergens.\u003C\/p\u003E\n\n\u003Cp\u003E\u003Cstrong\u003ECollaboration is key \u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\n\n\u003Cp\u003E\u2018One of the most difficult things up to now has been how to measure micro- and nanoplastics,\u2019 said Prof. Vermeulen. \u2018While microplastics can be seen under the microscope, nanoplastics are very difficult to detect, particularly in biological tissues. This is why we\u2019re really pushing to advance the methods. Before we can start to measure them in the placentas of a few hundred mothers and babies, we need to scale up the methods.\u2019\u0026nbsp;\u003C\/p\u003E\n\n\u003Cp\u003EThis is where the value of the CUSP cluster will be most visible. The five research consortia will contribute to uncovering exposure routes and developing new analytical tools. In this effort, cooperation is foreseen with the European Commission\u2019s Joint Research Centre.\u003C\/p\u003E\n\n\u003Cp\u003E\u2018There are a lot of analytical constraints when analysing microplastics and we lack the standardised methods and reference materials,\u2019 explained Prof. Cirkovic Veli\u010dkovi\u0107. \u2018In this regard, the research actions that will be taken by our cluster can move forward the methodology.\u2019\u003C\/p\u003E\n\n\u003Cp\u003EProf. Vermeulen agrees. \u2018Our collective wisdom is crucial,\u2019 he said. \u2018By communicating our findings within the cluster and working together, we can accelerate even faster than if we were working in isolation. For instance, if some researchers observe that a particle might attain or cross the lung barrier, then that particle might be of more interest for us to test. After all, what we are all doing is new and the knowledge needs to be rapidly shared.\u2019\u003C\/p\u003E\n\n\u003Cp\u003E\u003Cdiv class=\u0022text-center bg-bluelightest p-12 my-12 -mx-16\u0022\u003E\n  \u003Ch3 class=\u0022font-sans font-bold text-blue uppercase text-lg mb-8\u0022\u003EThe five CUSP projects\u003C\/h3\u003E\n  \u003Cspan class=\u0022inline-block w-1\/6 h-1 bg-blue mb-8\u0022\u003E\u003C\/span\u003E\n  \u003Cp\u003EThe \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/964827\u0022\u003EAURORA \u003C\/a\u003Eproject will focus on MNP exposures during pregnancy and early life and study their impact on reproductive and early-life health. It will develop novel tools for measuring MNPs in human tissues. It will then scale up these analytical methods to be able to detect plastic particles in placentas, blood and umbilical fluid \u2013 if they are present. The project includes epidemiological investigations to provide the first extensive evaluation of maternal and foetal MNP exposures and health perturbations, including placental function, immune-inflammatory responses and child development.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965173\u0022\u003EImptox \u003C\/a\u003Eproject will evaluate the influence of ingested and inhaled exposure of MNPs contaminated with metals, allergens, pathogenic bacteria and toxins on allergic responses. It includes a clinical study to evaluate the influence of MNP exposures to humans.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965196\u0022\u003EPLASTICHEAL \u003C\/a\u003Eproject will develop new methodologies and produce reliable scientific evidence for regulators to support risk assessment of MNPs. It will investigate the impact of MNPs on human health, drawing a variety of experimental human models and measuring potential health effects under short and long-term exposure conditions. It will generate human exposure estimates after identification, measurement, and characterisation of MNPs present in the environmental air, water and food sources, as well as in human biological samples of population groups with potential high MNPs exposure levels (biomonitoring study).\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/965367\u0022\u003EPlasticsFatE \u003C\/a\u003Eproject will improve our present understanding of the impact of MNPs and associated additives and adsorbed contaminants in the human body. It will establish validated methods to measure MNPs in complex matrices such as food (vegetables, fruits, beverages, fish etc.), human tissues and consumer products (toothpaste, beauty products), as well as relevant environmental media (air, drinking water, soils), assess relevant exposure levels\/sources, fate and toxicity in the human body by using advanced cell culture and organ models that simulate real exposure to MNPs in the respiratory and gastro-intestinal tract.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe \u003Ca href=\u0022https:\/\/cordis.europa.eu\/project\/id\/964766\u0022\u003EPOLYRISK \u003C\/a\u003Eproject will unravel the risks of MNPs that are ubiquitous in our environment and are likely to be entering the human body via inhalation and ingestion. It will focus on key toxic events linked to several chronic inflammatory diseases. It will advance analytical methods to detect MNP in complex matrices, up-to-date fit-for-purpose hazard assessment technologies and multiple real-life human exposure scenarios.\u0026nbsp;\u003C\/p\u003E\r\n\n\u003C\/div\u003E\n\u003C\/p\u003E\n\n\u003Cp\u003E\u003Cem\u003EThe research in this article was funded by the EU. 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