[{"command":"add_css","data":[{"rel":"stylesheet","media":"all","href":"\/sites\/default\/files\/css\/css_-kTcRwkqPhQLsqEvdSSyU2XZ3CV5VEleXoE3_xZi2cg.css?delta=0\u0026language=cs\u0026theme=hm_theme\u0026include=eJxLzi9K1U8pKi1IzNErSa0oSSxKTdQtSi3OrEoFAJQ3Cqw"}]},{"command":"openDialog","selector":"#drupal-modal","settings":null,"data":"\u003Cdiv id=\u0022republish_modal_form\u0022\u003E\u003Cform class=\u0022modal-form-example-modal-form ecl-form\u0022 data-drupal-selector=\u0022modal-form-example-modal-form\u0022 action=\u0022\/cs\/article\/modal\/12835\u0022 method=\u0022post\u0022 id=\u0022modal-form-example-modal-form\u0022 accept-charset=\u0022UTF-8\u0022\u003E\u003Cp\u003EHorizon articles can be republished for free under the Creative Commons Attribution 4.0 International (CC BY 4.0) licence.\u003C\/p\u003E\n      \u003Cp\u003EYou must give appropriate credit. We ask you to do this by:\u003Cbr \/\u003E\n      1) Using the original journalist\u0027s byline\u003Cbr \/\u003E\n      2) Linking back to our original story\u003Cbr \/\u003E\n      3) Using the following text in the footer: This article was originally published in \u003Ca href=\u0027#\u0027\u003EHorizon, the EU Research and Innovation magazine\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003ESee our full republication guidelines \u003Ca href=\u0027\/horizon-magazine\/republish-our-stories\u0027\u003Ehere\u003C\/a\u003E\u003C\/p\u003E\n      \u003Cp\u003EHTML for this article, including the attribution and page view counter, is below:\u003C\/p\u003E\u003Cdiv class=\u0022js-form-item form-item js-form-type-textarea form-item-body-content js-form-item-body-content ecl-form-group ecl-form-group--text-area form-no-label ecl-u-mv-m\u0022\u003E\n        \n\u003Cdiv\u003E\n  \u003Ctextarea data-drupal-selector=\u0022edit-body-content\u0022 aria-describedby=\u0022edit-body-content--description\u0022 id=\u0022edit-body-content\u0022 name=\u0022body_content\u0022 rows=\u00225\u0022 cols=\u002260\u0022 class=\u0022form-textarea resize-vertical ecl-text-area\u0022\u003E\u003Ch2\u003EEU takes the lead in the search for new mpox treatments \u003C\/h2\u003E\u003Cp\u003EOn a Sunday evening in June 2022, a patient walked into a hospital in Rio de Janeiro. \u201cI remember it very clearly,\u201d says Mayara Secco, the doctor responsible for handling emergency cases that night.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cThe patient just returned from Europe and had a single lesion on his body. He didn\u2019t have fever or any other symptoms, but he was worried about what it could be.\u201d\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cAnd just like that, I ended up being the first doctor in Rio to diagnose mpox,\u201d says Secco, who works as an infectious diseases doctor and clinical researcher at the Evandro Chagas National Institute of Infectious Diseases-Oswaldo Cruz Foundation in Brazil.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ERio de Janeiro was one of the epicentres of the first mpox outbreak (clade IIb) in 2022, which\u0026nbsp;caused more than\u0026nbsp;\u003Ca href=\u0022https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20240812_mpox_external-sitrep_35.pdf\u0022\u003E99\u0026nbsp;000 cases and 208 deaths in 116 countries\u003C\/a\u003E.\u003C\/p\u003E\u003Cp\u003ESince then, Secco has been closely involved in the response to the mpox outbreak worldwide, including taking part in an EU-funded international initiative called\u0026nbsp;MPX-RESPONSE. It is\u0026nbsp;focused on improving understanding of the virus, increasing global preparedness and finding new treatments for the disease.\u003C\/p\u003E\u003Ch2\u003EInternational response\u003C\/h2\u003E\u003Cp\u003ESecco is now a lead clinician working on UNITY, an international clinical trial evaluating a new medicine for the treatment of adult patients with mpox. This is coordinated by the\u0026nbsp;MPX-RESPONSE clinical research network,\u0026nbsp;launched in 2022 in response to the outbreak.\u003C\/p\u003E\u003Cp\u003EThere is so far only one approved treatment for mpox, but its approval is based on animal studies only.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cThis is because we didn\u2019t have enough cases to do clinical trials on humans,\u201d explains MPX-RESPONSE coordinator Professor Yazdan Yazdanpanah, the director of ANRS Emerging Infectious Diseases at France\u2019s Inserm, the National Institute of Health and Medical Research.\u003C\/p\u003E\u003Cp\u003E\u003Cblockquote class=\u0022text-center text-blue font-bold text-2xl w-full lg:w-1\/2 border-2 border-blue p-12 my-8 lg:m-12 lg:-ml-16 float-left\u0022\u003E\n  \u003Cspan class=\u0022text-5xl rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n  \u003Cp class=\u0022font-serif italic\u0022\u003EThe challenge of studying mpox in Europe is that we fortunately dont have many cases.\u003C\/p\u003E\n  \u003Cfooter\u003E\n    \u003Ccite class=\u0022not-italic font-normal text-sm text-black\u0022\u003EProfessor Yazdan Yazdanpanah, MPX-RESPONSE\u003C\/cite\u003E\n  \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n\u003C\/p\u003E\u003Cp\u003EThree clinical trials are currently underway in various regions around the world, all aimed at evaluating the safety and efficacy of this treatment.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cThe challenge of studying mpox in Europe is that we fortunately don\u2019t have many cases,\u201d says Yazdanpanah. Which is why it is important to involve other regions.\u003C\/p\u003E\u003Cp\u003EFor Yazdanpanah, this international collaboration is crucial when dealing with infectious diseases. \u201cIf there is an epidemic somewhere, no matter where, we need to control it. That\u2019s the only way to be prepared and the best way to protect both those at the epicentre of the outbreak and the European population,\u201d he says.\u0026nbsp;\u003C\/p\u003E\u003Ch2\u003ESocial stigma\u003C\/h2\u003E\u003Cp\u003EMpox, previously known as monkeypox, is an infectious disease that spreads between people mainly through close physical contact. The disease commonly causes a painful rash or mouth sores, as well as other symptoms such as fever, headache and muscle ache.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMost people fully recover, but some patients can have severe complications. The impact of the disease also goes beyond just the physical symptoms.\u003C\/p\u003E\u003Cp\u003E\u201cIf you are diagnosed with mpox, you are asked to isolate at home for 21 days, but recovery sometimes takes even longer,\u201d says Secco.\u0026nbsp;\u201cYou are completely isolated for almost a month, which can lead to a lot of mental health challenges, as well as serious financial issues.\u201d\u003C\/p\u003E\u003Cp\u003EMpox is also associated with significant social stigma.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cDuring the 2022 outbreak, the disease mostly impacted men who have sex with men. This only intensifies the stigma and discrimination this population already faces. The current mpox situation is often compared to the start of the AIDS epidemic.\u201d\u0026nbsp;\u003C\/p\u003E\u003Ch2\u003EFocus on vulnerable populations\u0026nbsp;\u003C\/h2\u003E\u003Cp\u003EA new variant (clade Ib) has emerged more recently, primarily in Africa, with isolated cases also turning up in Europe. This appears to be a more virulent strain of the virus, of particular risk to children.\u003C\/p\u003E\u003Cp\u003EThis situation prompted the World Health Organization to declare in August 2024 a public health emergency of international concern\u0026nbsp;(PHEIC). This means it was classed as an extraordinary event with the potential to spread across borders and requiring swift international action.\u003C\/p\u003E\u003Cp\u003EProfessor Carlo Giaquinto, director of the Department of Women and Child Health at the University of Padua, Italy, agrees on the need for international collaboration in order to protect vulnerable populations.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EHe is the president of the Penta Foundation, an Italian non-profit that supports research and training in paediatric infectious diseases. The Foundation works with the University of Padua to coordinate another EU-funded research initiative called VERDI, which is working to better understand the impact of mpox in high-risk populations around the globe.\u003C\/p\u003E\u003Cp\u003E\u003Cblockquote class=\u0022text-center text-blue font-bold text-2xl w-full lg:w-1\/2 border-2 border-blue p-12 my-8 lg:m-12 lg:-ml-16 float-left\u0022\u003E\n  \u003Cspan class=\u0022text-5xl rotate-180\u0022\u003E\u201c\u003C\/span\u003E\n  \u003Cp class=\u0022font-serif italic\u0022\u003EWe need to be prepared for new viruses and diseases, and mpox is a good example to test our level of preparedness.\u003C\/p\u003E\n  \u003Cfooter\u003E\n    \u003Ccite class=\u0022not-italic font-normal text-sm text-black\u0022\u003EProfessor Carlo Giaquinto, VERDI \u003C\/cite\u003E\n  \u003C\/footer\u003E\n\u003C\/blockquote\u003E\n\u003C\/p\u003E\u003Cp\u003EGiaquinto, an experienced paediatrician who has worked in the field for over 40 years, is concerned by the most recent outbreak of mpox.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cThere is now a new clade of mpox which is much more common in children,\u201d says Giaquinto. \u201cWe don\u2019t have a lot of experience with mpox in Europe, but from our studies in Africa, we know that mortality among children is four times higher than in adults.\u201d\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThis makes it crucial to find an effective treatment for children too, he stresses. \u201cWe need more studies on this topic and to develop strategies to effectively treat the disease.\u201d\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe VERDI research team\u0026nbsp;unites 30 research centres of excellence in Europe, the USA, Africa, the Caribbean, the Middle East and Southeast Asia. It is coordinated by the\u0026nbsp;University of Padua and\u0026nbsp;Penta Foundation, with scientific coordination shared between the University of Padua and University College London.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFaced with the mpox outbreak, they were able to draw on their previous experience in studying COVID-19 to quickly mobilise their infrastructure to face the new threat.\u0026nbsp;\u003C\/p\u003E\u003Ch2\u003EAwaiting results\u003C\/h2\u003E\u003Cp\u003EAccording to Giaquinto, however, the first outcome of the project is the fact that Europe now has an infrastructure that can very quickly respond to a new epidemic. As the research is still ongoing, it is expected that more concrete results will come.\u003C\/p\u003E\u003Cp\u003E\u201cWe need to be prepared for new viruses and diseases, and mpox is a good example to test our level of preparedness \u2013 and that is precisely what we have been doing in VERDI.\u201d\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EResearchers involved in the MPX-RESPONSE trials are also anxiously awaiting results. Although the outcome is impossible to predict, Secco already sees a positive impact that goes beyond clinical outcomes.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cFrom experience, I know that people with mpox always felt very anxious and scared because there was no treatment we could offer them,\u201d she says. \u201cOur participants really embrace the trial because they feel like they are contributing to science, but also to the LGBTQIA+ community, which has been impacted the most.\u201d\u003C\/p\u003E\u003Cp\u003EWary of building expectations, Secco is nevertheless hoping for a positive outcome. \u201cI really hope it will lead to something that improves people\u2019s quality of life\u0026nbsp;and contributes to the mpox response globally.\u201d\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EResearch in this article was funded by the EU\u2019s Horizon Programme. The views of the interviewees don\u2019t necessarily reflect those of the European Commission. 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